Obese mice are less able to fight off bacterial infection than lean mice, according to a study released Monday that supports emerging evidence of a link between obesity and a dysfunctional immune system.
In a study on laboratory mice infected with a bug that causes periodontal disease, obese mice had a blunted immune response to the infection and increased susceptibility to gum disease compared to lean mice.
The obese mice also had much higher rates of bone loss.
When researchers examined the rodents 10 days after they were infected with the bacterium Porphyromonas gingivalis, the heavier mice had a 40 percent increase in alveolar bone loss than the lean mice.
The alveolar bone is the bone or ridge that contains the tooth sockets on the upper and lower jaw.
Previous studies have shown that obese people are more likely to suffer from periodontal disease than their leaner counterparts and this study provided some clues as to why that is.
Blood tests on mice that had been infected with the bacterium P. gingivalis revealed irregularities in the production of cytokines in the obese mice, compared to the "control" or lean mice.
Full Article:
http://news.smh.com.au/obesity-linked-to-weaker-immunity-in-animals-study/20071211-1gbm.html
