Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients with coronary artery disease.
This entry was posted on 4/4/2008 11:16 AM and is filed under Research.
Palikhe A,
Lokki ML,
Pussinen PJ,
Paju S,
Ahlberg J,
Asikainen S,
Seppänen M,
Valtonen V,
Nieminen MS,
Sinisalo J.
Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Periodontitis and coronary artery disease (CAD) are inflammatory diseases and associated with each other. The major histocompatibility complex (MHC) region carries genes involved in immune response and inflammation. We investigated whether the MHC genes correlate with the presence of periodontitis or with the occurrence of periodontal pathogens in patients with CAD. Blood and saliva samples from CAD patients (n = 106) were collected at the time of hospitalization. Nine MHC genetic markers [human leukocyte antigen (HLA)-A, HLA-B, HLA-DRB1, lymphotoxin alpha (LTA) +253(a/g), +496(C/T), +633(c/g), +724(C/A), C4A and C4
] were typed. Based on panoramic tomography, patients were categorized into nonperiodontitis and periodontitis groups. Two major periodontal pathogens, Aggregatibacter (Actinobacillus) actinomycetemcomitans and Porphyromonas gingivalis, were cultivated and polymerase chain reaction-amplified from salivary samples.
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