Detection of periodontal pathogens in coronary atherosclerotic plaques
This entry was posted on 4/9/2008 11:19 AM and is filed under Research.
Zhong LJ,
Zhang YM,
Liu H,
Liang P,
Murat AR,
Askar S.
Department of Stomatology, First Affiliated Hospital, Xinjiang Medical University, Urümqi 830054, China.
OBJECTIVE: To explore the possible correlation between coronary heart disease and periodontitis. METHODS: Subgingival plaque samples and coronary atherosclerotic plaques were harvested from a total of 31 patients with periodontitis who scheduled for coronary artery bypass surgery. The bacteria DNA was obtained from subgingival plaque samples and coronary atherosclerotic plaques using the chelex-100 method. The extracted DNA was examined using the polymerase chain reaction (PCR) technique. RESULTS: In coronary atherosclerotic plaques samples from the 31 patients, Porphyromonas gingivalis (Pg, 38.7%), Actinobacillus actinomycetemcomitans (Aa, 0%), Fusobacterium nucleatum (Fn, 22.6%), Prevotella intermedia (Pi, 12.9%), Bacteroides forsythus (Bf, 38.7%) were detected. The concordant presence of the same periodontal bacteria DNA in subgingival plaques and in coronary atherosclerotic plaques in the same patient was Pg 5 (16.1%), Aa 0 (0%), Pi 2 (6.5%), Fn 4 (12.9%) and Bf 8 (25.8%). CONCLUSIONS: The presence of periodontal bacteria DNA in coronary atherosclerotic plaques could indicate that periodontal pathogenic bacteria may play a role in the coronary heart disease process.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2008 Jan;43(1):4-7.
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